Title of article
Carbaporphyrin ketals as potential agents for a new photodynamic therapy treatment of leishmaniasis Original Research Article
Author/Authors
Justin B. Morgenthaler، نويسنده , , Steven J. Peters، نويسنده , , David L. Cede?o، نويسنده , , Manuel H. Constantino، نويسنده , , Kevin A. Edwards، نويسنده , , Erin M. Kamowski، نويسنده , , Jennifer C. Passini، نويسنده , , Brian E. Butkus، نويسنده , , Alexandra M. Young، نويسنده , , Timothy D. Lash، نويسنده , , Marjorie A. Jones، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
6
From page
7033
To page
7038
Abstract
Dimethyl and diethyl carbaporphyrin ketals inhibit the growth of Leishmania tarentolae promastigotes in vitro. The concentration dependency of the inhibitory effect was tested using the MTT assay. The presence of reactive oxygen species, such as singlet oxygen and superoxide, was detected using electron paramagnetic resonance spectroscopy with selected spin traps and confocal microscopy in cultures exposed to these carbaporphyrin ketals. These unique porphyrinoids show promise as potent inhibitors of Leishmania.
Keywords
Leishmania , EPR , Photodynamic therapy , Carbaporphyrin ketal , Reactive oxygen species
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306748
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