Title of article
Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine–naphthalimide conjugates linked through piperazine side-armed alkane spacers Original Research Article
Author/Authors
Ahmed Kamal، نويسنده , , R. Ramu، نويسنده , , Venkatesh Tekumalla، نويسنده , , G.B. Ramesh Khanna، نويسنده , , Madan S. Barkume، نويسنده , , Aarti S. Juvekar، نويسنده , , Surekha M. Zingde، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
7
From page
7218
To page
7224
Abstract
A series of pyrrolobenzodiazepine–naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines.
Keywords
Pyrrolobenzodiazepines , naphthalimides , Piperazine ring , DNA binding affinity , Anticancer activity
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306769
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