Title of article
Microwave-assisted solid phase synthesis, PEGylation, and biological activity studies of glucagon-like peptide-1(7–36) amide Original Research Article
Author/Authors
Yushi Chi، نويسنده , , Huibin Zhang، نويسنده , , Wenlong Huang، نويسنده , , Jinpei Zhou، نويسنده , , Yinghong Zhou، نويسنده , , Hai Qian، نويسنده , , Shuaijian Ni، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
7607
To page
7614
Abstract
The insulinotropic hormone glucagon-like peptide-1 (GLP-1) is rapidly inactivated in the body. In order to improve its stability, we replaced the enzymatic hydrolyzation position Ala8with Gly and replaced Ala30 with Cys firstly. Then the modified peptide was further PEGylated at thiol group of Cys30. Biological activity studies showed that the resulting mPEG-MAL-Gly8-Cys30-GLP-1(7–36)-NH2 exhibited long-lasting effect while maintaining moderate glucose-lowering activity.
Keywords
GLP-1 , Microwave , Pegylation , DPP IV , Glucose-lowering effect
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306814
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