Title of article
New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell lines Original Research Article
Author/Authors
Laïla El kihel، نويسنده , , Monique Clément، نويسنده , , Marc-Antoine Bazin، نويسنده , , Géraldine Descamps، نويسنده , , Mohamed Khalid، نويسنده , , Sylvain Rault، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
8
From page
8737
To page
8744
Abstract
Six new synthetic bile acid derivatives were synthesized and tested in vitro against various human cancer cells (glioblastoma multiforme (GBM), multiple myeloma (KMS-11), and colonic carcinoma (HCT-116) cell lines. The best activity was obtained with compound IIIb on multiple myeloma cells (LD50: 8.5 ± 0.5 μM). This activity was associated with Mcl-1 and PARP-1 cleavage, inhibition of NFκB signaling, and DNA fragmentation, demonstrating an apoptotic cell death signaling pathway.
Keywords
Steroid-heterocycle , Bile acid derivatives , apoptosis , Multiple myeloma , Anticancer
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306890
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