Title of article
Preparation of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives as novel arginine vasopressin V2 receptor agonists Original Research Article
Author/Authors
Issei Tsukamoto، نويسنده , , Hiroyuki Koshio، نويسنده , , Seijiro Akamatsu، نويسنده , , Takahiro Kuramochi، نويسنده , , Chikashi Saitoh، نويسنده , , Takeyuki Yatsu، نويسنده , , Hiroko Yanai-Inamura، نويسنده , , Chika Kitada، نويسنده , , Eisaku Yamamoto، نويسنده , , Shuichi Sakamoto، نويسنده , , Shin-ichi Tsukamoto، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
12
From page
9524
To page
9535
Abstract
The present work describes the discovery of novel series of (4,4-difluoro-1,2,3,4-tetrahydro-5H-1-benzazepine-5-ylidene)acetamide derivatives as arginine vasopressin (AVP) V2 receptor agonists. By replacing the amide juncture in YM-35278 with a direct ring connection gave compound 10a, which acts as a V2 receptor agonist. These studies provided the potent, orally active non-peptidic V2 receptor agonists 10a and 10j.
Keywords
4-difluoro-1 , 2 , 4-tetrahydro-5H-1-benzazepin-5-ylidene)acetamide derivatives , V2 receptor agonist , Urine volume , V2 receptor antagonist , (4 , 3
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306981
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