Title of article
Thiopyrano[2,3-e]indol-2-ones: Angelicin heteroanalogues with potent photoantiproliferative activity Original Research Article
Author/Authors
Paola Barraja، نويسنده , , Patrizia Diana، نويسنده , , Alessandra Montalbano، نويسنده , , Anna Carbone، نويسنده , , Girolamo Cirrincione، نويسنده , , Giampietro Viola، نويسنده , , Alessia Salvador، نويسنده , , Daniela Vedaldi، نويسنده , , Francesco Dall’Acqua، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
16
From page
9668
To page
9683
Abstract
A new class of compounds, the thiopyrano[2,3-e]indol-2-ones, bioisosters of the angular furocoumarin angelicin, was synthesized with the aim of obtaining new photochemotherapeutic agents. In particular 7,8-dimethyl-thiopyranoindolone 6c s showed a remarkable phototoxicity and a great dose UVA dependence reaching IC50 values at submicromolar level. This latter photoinduced a massive apoptosis and a remarkable photodamage to lipids and proteins. Although it did not intercalate DNA, it was able to cause photooxidation of DNA bases.
Keywords
3-e]indol-2-ones , Angelicin , Photochemotherapeutic agents , antiproliferative activity , apoptosis
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2008
Journal title
Bioorganic and Medicinal Chemistry
Record number
1306995
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