Author/Authors :
Pelayo Camps، نويسنده , , Mar?a D. Duque، نويسنده , , Santiago V?zquez، نويسنده , , Lieve Naesens، نويسنده , , Erik De Clercq، نويسنده , , Francesc X. Sureda، نويسنده , , Marta L?pez-Querol، نويسنده , , Antoni Camins، نويسنده , , Merce Pallàs، نويسنده , , S. Radhika Prathalingam، نويسنده , , John M. Kelly، نويسنده , , Vanessa Romero، نويسنده , , Dolores Ivorra، نويسنده , , Diego Cortes، نويسنده ,
Abstract :
The synthesis of several (3-noradamantyl)amines, [(3-noradamantyl)methyl]amines, (3,7-dimethyl-1-bisnoradamantyl)amines, and [(3,7-dimethyl-1-bisnoradamantyl)methyl]amines is reported. They were evaluated against a wide range of viruses and one of them inhibited the cytopathicity of influenza A virus at a concentration similar to that of amantadine. Several of the new polycyclic amines show an interesting activity as NMDA receptor antagonists. A rimantadine analogue displayed significant trypanocidal activity. Moreover, to further characterize the pharmacology of these compounds, their effects on dopamine uptake were also assessed.
Keywords :
Memantine , Polycyclic cage compounds , trypanosomiasis , Amantadine , NMDA receptor antagonist , Influenza
