Title of article
Proteasome inhibition in human breast cancer cells with high catechol-O-methyltransferase activity by green tea polyphenol EGCG analogs Original Research Article
Author/Authors
Congde Huo، نويسنده , , Huanjie Yang، نويسنده , , Qiuzhi Cindy Cui، نويسنده , , Q. Ping Dou، نويسنده , , Tak Hang Chan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
7
From page
1252
To page
1258
Abstract
A pro-drug 8 of a synthetic analog 7 is more active in its antiproliferative activity against human breast cancer MDA-MB-231 cells possessing high catechol-O-methyltransferase (COMT) activity than the pro-drugs of EGCG and the analog 5. The higher activity of 8 is attributed to it not being a substrate of COMT.
Keywords
Endo-M , Transglycosylation , Chemo-enzymatic synthesis , Insulin , Modification of protein
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307124
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