Title of article
Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I) Original Research Article
Author/Authors
Yonggang Li، نويسنده , , Jian Zhang، نويسنده , , Wenfang Xu، نويسنده , , and Huawei Zhu، نويسنده , , Xun Li، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
10
From page
1516
To page
1525
Abstract
A series of quinoxalinone peptidomimetic derivatives was designed, synthesized, and assayed for their inhibitory activities on metalloproteinase-2 (MMP-2) and aminopeptidase N (APN). The results showed that all of these quinoxalinone derivatives displayed highly selective inhibition against MMP-2 as compared with APN, with IC50 values in the micromole range. Compound A3 showed comparable MMP-2 inhibitory activities than the positive control LY52, which might be used as a potential lead in future research on anticancer agents.
Keywords
Anti-tumor , Quinoxalinone derivatives , MMP-2 inhibitors , Peptidomimetic
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307154
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