Author/Authors :
M.V. Ramana Reddy، نويسنده , , Venkat R. Pallela، نويسنده , , Stephen C. Cosenza، نويسنده , , Muralidhar R. Mallireddigari، نويسنده , , Revathi Patti، نويسنده , , Marie Bonagura، نويسنده , , May Truongcao، نويسنده , , Balaiah Akula، نويسنده , , Shashidhar S. Jatiani، نويسنده , , E. Premkumar Reddy، نويسنده ,
Abstract :
Novel (E)-α-benzylthio chalcones are reported with preliminary in vitro activity data indicating that several of them are potent inhibitors (comparable to imatinib, the reference compound) of BCR-ABL phosphorylation in leukemic K562 cells, known to express high levels of BCR-ABL. The ability of such compounds to significantly inhibit K562 cell proliferation suggests that this scaffold could be a promising lead for the development of anticancer agents that are able to block BCR-ABL phosphorylation in leukemic cells.
