Title of article
Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton Original Research Article
Author/Authors
Masahiko Nakamura، نويسنده , , Atsushi Aoyama، نويسنده , , Mohammed T.A. Salim، نويسنده , , Mika Okamoto، نويسنده , , Masanori Baba، نويسنده , , Hiroyuki Miyachi، نويسنده , , Yuichi Hashimoto، نويسنده , , Hiroshi Aoyama، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
10
From page
2402
To page
2411
Abstract
A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6(5H)-one (10) and 5-butylbenzo[b]phenanthridin-6(5H)-one (39), which showed EC50 values of approximately 3.7 and 3.2 μM, respectively.
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307244
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