Title of article :
Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton Original Research Article
Author/Authors :
Masahiko Nakamura، نويسنده , , Atsushi Aoyama، نويسنده , , Mohammed T.A. Salim، نويسنده , , Mika Okamoto، نويسنده , , Masanori Baba، نويسنده , , Hiroyuki Miyachi، نويسنده , , Yuichi Hashimoto، نويسنده , , Hiroshi Aoyama، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6(5H)-one (10) and 5-butylbenzo[b]phenanthridin-6(5H)-one (39), which showed EC50 values of approximately 3.7 and 3.2 μM, respectively.
Journal title :
Bioorganic and Medicinal Chemistry
Journal title :
Bioorganic and Medicinal Chemistry
