Author/Authors :
Savina Malancona، نويسنده , , Monica Donghi، نويسنده , , Marco Ferrara، نويسنده , , Josè I. Martin Hernando، نويسنده , , Marco Pompei، نويسنده , , Silvia Pesci، نويسنده , , Jesus M. Ontoria، نويسنده , , Uwe Koch، نويسنده , , Michael Rowley، نويسنده , , Vincenzo Summa، نويسنده ,
Abstract :
Chronic hepatitis C virus (HCV) infections are a significant medical problem worldwide. The NS5B Polymerase of HCV plays a central role in virus replication and is a prime target for the discovery of new treatment options. We recently disclosed 1H-benzo[de]isoquinoline-1,3(2H)-diones as allosteric inhibitors of NS5B Polymerase. Structural and SAR information guided us in the modification of the core structure leading to new templates with improved activity and toxicity/activity window.
