Title of article
Antitumor activity and COMPARE analysis of bis-indole derivatives Original Research Article
Author/Authors
Aldo Andreani، نويسنده , , Silvia Burnelli، نويسنده , , Massimiliano Granaiola، نويسنده , , Alberto Leoni، نويسنده , , Alessandra Locatelli، نويسنده , , Rita Morigi، نويسنده , , Mirella Rambaldi، نويسنده , , Lucilla Varoli، نويسنده , , Laura Landi، نويسنده , , Cecilia Prata*، نويسنده , , Francesco Vieceli Dalla Sega، نويسنده , , Cristiana Caliceti، نويسنده , , Robert H. Shoemaker، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
8
From page
3004
To page
3011
Abstract
This paper reports the synthesis of new derivatives (formed by two indole systems separated by a central moiety) analogous of potent antitumor agents previously described. The activity of the bis-indoles bearing a pyridine core confirms the good result described in the previous paper and compound 4c was chosen for the first in vivo experiment (Hollow Fiber Assay). COMPARE analysis and structure–activity relationships were also considered. Contrary to data reported by other Authors, no correlations were found between antitumor activity and NQO1 induction.
Keywords
Pyridine , Hollow fiber assay , Antitumor , COMPARE , NQO1 , Indole
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307303
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