Title of article
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans Original Research Article
Author/Authors
Barbara Czak?، نويسنده , , J?nos Marton، نويسنده , , S?ndor Berényi، نويسنده , , Katarzyna Gach، نويسنده , , Jakub Fichna، نويسنده , , Martin Storr، نويسنده , , Geza Toth، نويسنده , , Attila Sipos، نويسنده , , Anna Janecka، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
8
From page
3535
To page
3542
Abstract
A set of novel 6-substituted orvinols was synthesized and pharmacologically characterized in order to explore the effect of the polarity and steric effects of these new moieties on the opioid activity. It was revealed that longer 6-O-alkyl chains led to increased agonistic activities, while the lack of C6-etheral oxygen gave rise to an antagonistic profile at the opioid receptors in the mouse ileum.
Keywords
Analgesics , Orvinols , Partial agonism , Drug abuse , DFT study
Journal title
Bioorganic and Medicinal Chemistry
Serial Year
2010
Journal title
Bioorganic and Medicinal Chemistry
Record number
1307354
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