Title of article :
Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines
Author/Authors :
A. Zainelabdeen A. Mustafa، نويسنده , , Muhammad Qayyum Khan Muhammad Altaf Hussain، نويسنده , , M. Monim-ul-Mehboob، نويسنده , , Mohammed Fettouhi، نويسنده , , Mohammed I.M Wazeer، نويسنده , , Anvarhusein A. Isab، نويسنده , , Vikram Dhuna، نويسنده , , Gaurav Bhatia، نويسنده , , Kshitija Dhuna، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
This communication reports on the synthesis, crystal structure and anticancer activities of a new Pt(II) complex [Pt(Diaz)4]Cl2 · H2O of a heterocyclic thione, where Diaz = 1,3-diazinane-2-thione. Solid state 195Pt, 15N and 13C NMR are also reported along with other spectroscopic data. The cytotoxic evaluation of the complex against A549, MCF7, HCT15 and HeLa human cancer lines is reported. The title compound was found to be a better cytotoxic agent against MCF7 than cisplatin.
Keywords :
Dichloridotetrakis(1 , Single crystal X-ray structure , 195Pt NMR , In vitro cytotoxicity studies , 3-diazinane-2-thione) platinum(II) complex
Journal title :
Inorganic Chemistry Communications
Journal title :
Inorganic Chemistry Communications
