Synthesis, crystal structure and antimicrobial studies of a thione derivative of transplatin, trans-[Pt(NH3)2(Diaz)2]Cl2·2H2O (Diaz = 1,3-diazinane-2-thione)

Platinum(II) complexes, trans-[Pt(NH3)2(Diaz)2]Cl2·2H2O (1) and trans-[Pt(NH3)2(Tu)2]Cl2 (Diaz = 1,3-diazinane-2-thione, Tu = thiourea) were prepared and characterized by elemental analysis, IR and NMR spectroscopy. The crystal structure of compound 1 was determined by X-ray crystallography. The structure of 1 consists of trans-[Pt(NH3)2(Diaz)2]2 + cation, two chloride ions and two water molecules. In trans-[Pt(NH3)2(Diaz)2]2 +, the geometry at platinum is nearly regular square planar with the average cis and trans angles of 90° and 180° respectively. The 1H and 13C NMR spectral data indicated the coordination of both ligands to platinum(II). Antimicrobial activities of the complexes were evaluated by minimum inhibitory concentration and the results showed that the complexes exhibited significant activities against gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa). However, moderate activity was observed against molds (Aspergillus niger, Penicillium citrinum).