The first carboranyl bis(adenosine diphosphate) (CBADP): a synthetic investigation

The synthesis of the first carboranyl bis(adenosine diphosphate) (CBADP) (5) was achieved in three steps. The first step involved the reaction of o-carborane dianion, 1, with methyl dichlorophosphate to yield 2. Reagent 4 was synthesized by the reaction of bis-benzoyl-protected adenosine with phosphoryl chloride, followed by the protection of the free hydroxyl group in the product, 3, with methyl triflate. The final step converged both 2 and 4 into the title compound, CBADP (5).