New gold(I) and silver(I) complexes of sulfamethoxazole: Synthesis, X-ray structural characterization and microbiological activities of triphenylphosphine(sulfamethoxazolato-N2)gold(I) and (sulfamethoxazolato)silver(I)

Sulfamethoxazole (SMTZ) reacts with Ph3PAuCl and AgCl in methanol/triethylamine to give [Ph3PAu(SMTZ-1H+)] (SMTZ-1H+ = sulfamethoxazolato anion) (1) and [Ag(SMTZ-1H+)] (2). While the lattice of 1 contains single molecules with linear N–Au–P bonds, compound 2 comprises a two-dimensional polymeric assembly of the deprotonated SMTZ ligand and silver ions, which are coordinated by one oxygen and three nitrogens in a distorted tetrahedral array. The microbiologic activities (Mueller–Hinton broth dilution tests) of 1 and 2 were determined in relation to free sulfamethoxazole.