Title of article
Striking medium effects on the kinetics of decomposition of macrocyclic Cu2+ complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals
Author/Authors
Manuel G. Basallote، نويسنده , , Carmen E. Castillo، نويسنده , , M. Angeles M??ez، نويسنده , , P?emysl Lubal، نويسنده , , Manuel Mart?nez، نويسنده , , Carlos Rodr?guez، نويسنده , , Jakub Van?k، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
3
From page
1272
To page
1274
Abstract
The kinetics of decomposition of a macrocyclic Cu2+ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different Cl− concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing 64Cu radiopharmaceuticals.
Keywords
Decomposition of copper complexes , kinetics , Electrolyte media , Copper-64 radiopharmaceuticals
Journal title
Inorganic Chemistry Communications
Serial Year
2010
Journal title
Inorganic Chemistry Communications
Record number
1318648
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