Author/Authors :
Bal?zs Kripli، نويسنده , , G?bor Bar?th، نويسنده , , E. Balogh-Hergovich، نويسنده , , Michel Giorgi، نويسنده , , A. Jalila Simaan، نويسنده , , L?szl? P?rk?nyi، نويسنده , , J?zsef S. Pap، نويسنده , , J?zsef Kaizer، نويسنده , , G?bor Speier، نويسنده ,
Abstract :
Hexacoordinate, high-spin iron(II) complexes with different isoindoline-derivative ligands have been prepared and characterized. The Fe3+/Fe2+ redox transition is reversible in each case, but the E1/2 values vary in a ~ 400 mV range depending on the ligand. SOD-like activity of the complexes was determined by indirect methods with cytochrome c, and nitroblue tetrazolium indicator at pH 7.6. The measured activities correlate with the redox potentials for the Fe3+/Fe2+ couples. The results indicate that the superoxide dismutation takes place via an inner-sphere mechanism at the iron site.
Keywords :
Iron , SOD mimics , Redox chemistry , Isoindoline ligand
