Synthesis and characterization of platinum(II) oligopyridine-peptide conjugates

Complexes of the general formulae [Pt(trpy)(cpy)]NO3, where cpy = pyridine-2-carboxylic acid, pyridine-3-carboxylic and pyridine-4-carboxylic acid (1)–(3), have been synthesized and characterized. The molecular structure of (3) has been determined by X-ray single crystal diffraction. The resin-immobilized ligand Lys-Lys-4-CO-py (L) interacts with the [Pt(trpy)H2O](NO3)2 via solid phase synthesis, forming the complex [Pt(trpy)(4-CO-py-Lys1-Lys2CONH2)](NO3)4, which has been characterized by 1H NMR and mass spectrometry.