Title of article
Rhodium(III) complexes with polypyridyls and pyrazole and their antitumor activity
Author/Authors
Florian P. Pruchnik، نويسنده , , Piotr Jakimowicz، نويسنده , , Zbigniew Ciunik، نويسنده , , Jolanta Zakrzewska-Czerwi?ska، نويسنده , , Adam Opolski، نويسنده , , Joanna Wietrzyk، نويسنده , , El?bieta Wojdat، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
8
From page
59
To page
66
Abstract
Synthesis and properties of rhodium complexes with nitrogen ligands [RhCl2(Hpz)4][RhCl4(Hpz)2] (1), [RhCl3(tpy)] (2), [RhCl3(tpta)]·H2O (3) and [Rh(tpy)2(Him)]Cl3·3H2O (4), have been described. X-ray structures of complexes 1–3 have been determined. IR, UV–Vis and 1H NMR spectra of the complexes have been discussed. Cytostatic activity of the complexes against HCV29T tumor cells increases in the series: 1<3<2<4. The cytostatic activity of complex 4 is greater than that of cisplatin. Interaction of the complexes with DNA has been investigated.
Keywords
Rhodium(III) complexes , Cytostatic activity , Antitumor
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2002
Journal title
INORGANICA CHIMICA ACTA
Record number
1321294
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