Title of article :
Synthesis, characterization and cytotoxicity studies of platinum(II) complexes with reduced amino acid ester Schiff-bases as ligands
Author/Authors :
Li، نويسنده , , Li-Jun and Fu، نويسنده , , Bin and Qiao، نويسنده , , Yu and Wang، نويسنده , , Cheng and Huang، نويسنده , , Ying-Ying and Liu، نويسنده , , Chuan-Chuan and Tian، نويسنده , , Chao and Du، نويسنده , , Jian-Long، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2014
Abstract :
A series of platinum(II) complexes with reduced amino acid esters Schiff-bases as ligands were prepared as potential anticancer agents and characterized by NMR, IR spectroscopy, elemental analysis and molar conductivity. These compounds were tested for their stability and DNA interaction with salmon sperm DNA by ultraviolet spectrum. The cytotoxicities of these complexes were validated against HL-60, BGC-823, Hela, and HepG2 cell lines by the MTT test. The complexes 5e and 5f exhibited better cytotoxic activity than cisplatin against HepG2 and BGC-823 cell lines, respectively.
Keywords :
Platinum(II) complexes , Synthesis , Reduced amino acid esters Schiff-bases , Characterize , Antitumor activity , DNA interaction
Journal title :
INORGANICA CHIMICA ACTA
Journal title :
INORGANICA CHIMICA ACTA
