Title of article :
Copper(II) complexes with β-cyclodextrin–homocarnosine conjugates and their antioxidant activity
Author/Authors :
Francesco Bellia، نويسنده , , Diego La Mendola، نويسنده , , Giuseppe Maccarrone، نويسنده , , Placido Mineo، نويسنده , , Daniele Vitalini، نويسنده , , Emilio Scamporrino، نويسنده , , Salvatore Sortino، نويسنده , , Graziella Vecchio، نويسنده , , Enrico Rizzarelli، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2007
Pages :
10
From page :
945
To page :
954
Abstract :
Copper(II) complexes of the β-cyclodextrin (β-CD) functionalized with homocarnosine (HC) in the primary (CDHC6) and secondary rim (CDHC3) were characterized by means of different spectroscopic techniques such as UV–Vis absorption, circular dichroism, electron paramagnetic resonance and electron-spray mass spectrometry. Taken together, all the spectroscopic parameters indicate the formation of different copper(II) complex species at various pH values. In the CDHC3 copper(II) complex species, a direct involvement of the secondary hydroxyl group 2 of functionalized β-CD’s ring has been pointed out. The antioxidant activity of the copper(II) complexes of the two derivatives was determined through pulse radiolysis measurements. The results obtained provide direct evidence for a high catalytic activity of both complexes towards the dismutation of the superoxide anion radical. It is also demonstrated that the complex formation is not detrimental to the excellent scavenger activity exhibited by the ligands alone towards hydroxyl radicals. These copper complexes then represent very intriguing antioxidant agents against well known toxic reactive oxygen species.
Keywords :
Copper(II) complexes , Antioxidant activity , Cyclodextrin derivatives
Journal title :
INORGANICA CHIMICA ACTA
Serial Year :
2007
Journal title :
INORGANICA CHIMICA ACTA
Record number :
1324432
Link To Document :
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