Title of article :
Synthesis, characterization and biological studies of organotin(IV) complexes with hydrazone ligand
Author/Authors :
Md. Abu Affan، نويسنده , , Siong Wan Foo، نويسنده , , Ismail Jusoh، نويسنده , , Sulaiman Hanapi، نويسنده , , Edward R.T. Tiekink، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Abstract :
Four organotin(IV) complexes with general formula [RSnCln−1(TCB)] [R = Ph2, n = 2 (2); R = Me, n = 3 (3); R = Bu, n = 3 (4); R = Ph, n = 3 (5)] have been synthesized by direct reaction of thiophene-2-carboxaldehyde benzhydrazone ligand [HTCB, (1)], base and organotin(IV) chloride in absolute methanol under N2 atmosphere. All organotin(IV) complexes were characterized by elemental analyses, molar conductivity, UV–Vis, FT-IR, 1H and 13C NMR spectral studies. Among them, diphenyltin(IV) complex (2) has also been characterized by X-ray crystallography diffraction analyses. The cytotoxicity of the hydrazone ligand as well as its organotin(IV) complexes (2–5) were determined with Artemia salina. While no-choice bioassay was employed on Coptotermes sp. to evaluate the termiticidal effect of all the complexes. Besides, the ligand (1) and its organotin(IV) complexes (2–4) were also tested against five types of bacteria namely Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Salmonella typhi.
Keywords :
Hydrazone , Organotin(IV) complexes , Cytotoxicity , Anti-termite , Antibacterial , Spectral studies
Journal title :
INORGANICA CHIMICA ACTA
Journal title :
INORGANICA CHIMICA ACTA