Title of article
Platinum and ruthenium complexes of new long-tail derivatives of PTA (1,3,5-triaza-7-phosphaadamantane): Synthesis, characterization and antiproliferative activity on human tumoral cell lines
Author/Authors
Bergamini، نويسنده , , Paola and Marvelli، نويسنده , , Lorenza and Marchi، نويسنده , , Andrea and Vassanelli، نويسنده , , Francesca and Fogagnolo، نويسنده , , Marco and Formaglio، نويسنده , , Paolo and Bernardi، نويسنده , , Tatiana and Gavioli، نويسنده , , Riccardo and Sforza، نويسنده , , Fabio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
9
From page
162
To page
170
Abstract
The alkylation of PTA, (1,3,5-triaza-7-phosphaadamantane), with long chain alkyl iodides produced the novel ionic derivatives (PTAC12H25)I, (PTAC16H33)I and (PTAC18H37)I. Anion exchange gave the PF6− analogs (PTAC12H25)PF6, (PTAC16H33)PF6 and (PTAC18H37)PF6. The new phosphines were characterized by ESI-MS, elemental analysis, 1H, 13C, and 31P NMR spectroscopy and their coordination ability was investigated towards Pt(II) and Ru(II) cores. Complexes cis-[PtCl2(PTAR)](PF6)2 (1–3) and [CpRuCl(PPh3)(PTAR)]I (5–7) have been isolated and characterized. Antiproliferative activity, given as estimated IC50, was tested for each complex against appropriate human tumoral lines (T2, SKOV3 and SW480) in comparison with cisplatin, with the parent complexes [CpRuCl(PPh3)(PTA)] and [CpRuCl(PPh3)(PTAMe)]I and with the free ligands.
Keywords
N-Alkylation , Antiproliferative activity , Platinum , Ruthenium , PTA , Long chain alkyl
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2012
Journal title
INORGANICA CHIMICA ACTA
Record number
1331224
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