Cellular interactions of platinum drugs

This manuscript represents a critical review of selected topics relating to the cellular interactions of platinum anticancer drugs. The intent is not to provide a comprehensive summary of all the work described in the literature but to raise questions and cast doubts about selected topics regarding the approaches taken towards trying to elucidate the event that happens in cancer cells that were exposed to platinum complexes. The experimental methods used to study the cellular interactions of platinum complexes are reviewed and the significance of the results obtained from such studies is discussed.