Title of article
New PTA (1,3,5-triaza 7-phosphaadamantane) derivatives associating zwitterionic structure and coordinative ability
Author/Authors
Bergamini، نويسنده , , Paola and Marvelli، نويسنده , , Lorenza and Marchi، نويسنده , , Andrea and Bertolasi، نويسنده , , Valerio and Fogagnolo، نويسنده , , Marco and Formaglio، نويسنده , , Paolo and Sforza، نويسنده , , Fabio، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2013
Pages
8
From page
11
To page
18
Abstract
The reactions of PTA (1,3,5-triaza 7-phosphaadamantane) and HMTA (1,3,5,7-tetraazaadamantane) with 1,3-propanesultone or 1,4-butanesultone gave the water soluble zwitterionic derivatives PTA+C3H6SO3− (1), PTA+C4H8SO3− (2), HMTA+C3H6SO3− (3) and HMTA+C4H8SO3− (4). The crystal structure of HMTA+C3H6SO3 is reported. The coordinative ability of 1–4 towards Pt(II) and Ru(II) has been investigated and the antiproliferative activity of ligands and complexes has been tested in two human ovarian cancer cell lines, A2780 and SKOV3.
Keywords
PTA , Zwitterionic , Platinum , Antiproliferative activity , N-Alkylation , Ruthenium
Journal title
INORGANICA CHIMICA ACTA
Serial Year
2013
Journal title
INORGANICA CHIMICA ACTA
Record number
1331802
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