New PTA (1,3,5-triaza 7-phosphaadamantane) derivatives associating zwitterionic structure and coordinative ability

The reactions of PTA (1,3,5-triaza 7-phosphaadamantane) and HMTA (1,3,5,7-tetraazaadamantane) with 1,3-propanesultone or 1,4-butanesultone gave the water soluble zwitterionic derivatives PTA+C3H6SO3− (1), PTA+C4H8SO3− (2), HMTA+C3H6SO3− (3) and HMTA+C4H8SO3− (4). The crystal structure of HMTA+C3H6SO3 is reported. The coordinative ability of 1–4 towards Pt(II) and Ru(II) has been investigated and the antiproliferative activity of ligands and complexes has been tested in two human ovarian cancer cell lines, A2780 and SKOV3.