Author/Authors :
Nojavan، Mohammad نويسنده Hematology Department, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran , , Shamsasenjan، Karim نويسنده Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran. , , Movassaghpour، Ali Akbar نويسنده Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. , , Akbarzadehlaleh، Parvin نويسنده Pharmaceutical Biotechnology Department, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran , , Torabi، Seyd Esmail نويسنده Research Center of Iranian Blood Transfusion Organizations, Tehran, Iran , , Ghojazadeh، Morteza نويسنده PhD, Assistant Professor, Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran Ghojazadeh, Morteza
Abstract :
Introduction: ABO blood group system is the most important blood group in transfusion and has been widely used in population studies. Several molecular techniques for ABO allele’s detection are widely used for distinguishing various alleles of glycosyl transferase locus on chromosome 9. Methods: 744 randomly selected samples from Azari donors of East Azerbaijan province (Iran) were examined using well-adjusted multiplex allele- specific PCR ABO genotyping technique. Results: The results were consistent for all individuals. The ABO blood group genotype of 744 healthy Azari blood donors was: 25.8% AA/AO (2), 7.6% AO (1), 1.6% BB, 11.3% B0 (1), 10% AB, 9.3% 0(1)0(1) and 15.3%0(1)0(2). The highest genotype frequency belonged to O01/O02 genotype (15.3%) and the lowest frequency belonged to A101/A102 genotype (0.4%). Conclusions: The frequencies of ABO alleles didn’t show significant differences between East Azerbaijan province population and that of other areas of the country. Meanwhile, statistical analysis of frequencies of A and B alleles between East Azerbaijan province population and neighbor countries showed significant differences whereas the frequency of allele O between them did not show significant difference (P > 0.05).
