Endostatinʹs endpoints—Deciphering the endostatin antiangiogenic pathway

Up until now, the precise mechanism for endostatinʹs antiangiogenesis action was not known. In a recent report, Abdollahi et al. (2004) have taken advantage of gene array and proteomic analysis to map the antiangiogenic pathways turned on by endostatin. This study resolves some of the controversies surrounding endostatinʹs biology, and provides a new direction to help dissect the molecular pathways involved in endostatinʹs selective tumor antiangiogenic effects.