Author/Authors :
Bao، نويسنده , , Shideng and Ouyang، نويسنده , , Gaoliang and Bai، نويسنده , , Xuefang and Huang، نويسنده , , Zhi and Ma، نويسنده , , Chaoyu and Liu، نويسنده , , Ming and Shao، نويسنده , , Rong and Anderson، نويسنده , , Ryan M and Rich، نويسنده , , Jeremy N and Wang، نويسنده , , Xiao-Fan، نويسنده ,
Abstract :
Molecular mechanisms associated with tumor metastasis remain poorly understood. Here we report that acquired expression of periostin by colon cancer cells greatly promoted metastatic development of colon tumors. Periostin is overexpressed in more than 80% of human colon cancers examined with highest expression in metastatic tumors. Periostin expression dramatically enhanced metastatic growth of colon cancer by both preventing stress-induced apoptosis in the cancer cells and augmenting endothelial cell survival to promote angiogenesis. At the molecular level, periostin activated the Akt/PKB signaling pathway through the αvβ3 integrins to increase cellular survival. These data demonstrated that the survival-promoting function is crucial for periostin to promote tumor metastasis of colon cancer.
