Title of article :
Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
Author/Authors :
Michieli، نويسنده , , Paolo and Mazzone، نويسنده , , Massimiliano and Basilico، نويسنده , , Cristina and Cavassa، نويسنده , , Silvia and Sottile، نويسنده , , Antonino and Naldini، نويسنده , , Luigi and Comoglio، نويسنده , , Paolo M، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2004
Pages :
13
From page :
61
To page :
73
Abstract :
Met, the receptor for hepatocyte growth factor (HGF), is activated in human cancer by both ligand-dependent and -independent mechanisms. We engineered a soluble Met receptor (decoy Met) that interferes with both HGF binding to Met and Met homodimerization. By lentiviral vector technology, we achieved local or systemic delivery of decoy Met in mice. We provide evidence that in vivo expression of decoy Met (1) inhibits tumor cell proliferation and survival in a variety of human xenografts, (2) impairs tumor angiogenesis by preventing host vessel arborization, (3) suppresses or prevents the formation of spontaneous metastases, and (4) synergizes with radiotherapy in inducing tumor regression, without (5) affecting housekeeping physiological functions in the adult animal.
Journal title :
Cancer Cell
Serial Year :
2004
Journal title :
Cancer Cell
Record number :
1335449
Link To Document :
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