Author/Authors :
Cao، نويسنده , , Renhai and Bjِrndahl، نويسنده , , Meit A. and Religa، نويسنده , , Piotr and Clasper، نويسنده , , Steve and Garvin، نويسنده , , Stina and Galter، نويسنده , , Dagmar and Meister، نويسنده , , Bjِrn and Ikomi، نويسنده , , Fumitaka and Tritsaris، نويسنده , , Katerina and Dissing، نويسنده , , Steen and Ohhashi، نويسنده , , Toshio and Jackson، نويسنده , , David G. and Cao، نويسنده , , Yihai، نويسنده ,
Abstract :
Cancer metastases are commonly found in the lymphatic system. Like tumor blood angiogenesis, stimulation of tumor lymphangiogenesis may require the interplay of several tumor-derived growth factors. Here we report that members of the PDGF family act as lymphangiogenic factors. In vitro, PDGF-BB stimulated MAP kinase activity and cell motility of isolated lymphatic endothelial cells. In vivo, PDGF-BB potently induced growth of lymphatic vessels. Expression of PDGF-BB in murine fibrosarcoma cells induced tumor lymphangiogenesis, leading to enhanced metastasis in lymph nodes. These data demonstrate that PDGF-BB is an important growth factor contributing to lymphatic metastasis. Thus, blockage of PDGF-induced lymphangiogenesis may provide a novel approach for prevention and treatment of lymphatic metastasis.
