Author/Authors :
Planelles، نويسنده , , Lourdes and Carvalho-Pinto، نويسنده , , Carla E. and Hardenberg، نويسنده , , Gijs and Smaniotto، نويسنده , , Salette and Savino، نويسنده , , Wilson and G?mez-Caro، نويسنده , , Ruth and Alvarez-Mon، نويسنده , , Melchor and de Jong، نويسنده , , Joan and Eldering، نويسنده , , Eric E. Martinez-Garciai، نويسنده , , Carlos and Medema، نويسنده , , Jan Paul and Hahne، نويسنده , , Michael، نويسنده ,
Abstract :
A tumor-supporting role for the TNF-like ligand APRIL has been suggested. Here we describe that 9- to 12-month-old APRIL transgenic mice develop lymphoid tumors that originate from expansion of the peritoneal B-1 B cell population. Aging APRIL transgenic mice develop progressive hyperplasia in mesenteric lymph nodes and Peyerʹs patches, disorganization of affected lymphoid tissues, mucosal and capsular infiltration, and eventual tumor cell infiltration into nonlymphoid tissues such as kidney and liver. We detected significantly increased APRIL levels in sera of B cell chronic lymphoid leukemia (B-CLL) patients, indicating that APRIL promotes onset of B-1-associated neoplasms and that APRIL antagonism may provide a therapeutic strategy to treat B-CLL patients.
