Author/Authors :
Richardson، نويسنده , , Andrea L. and Wang، نويسنده , , Zhigang C. and De Nicolo، نويسنده , , Arcangela and Lu، نويسنده , , Xin Q. Brown، نويسنده , , Myles and Miron، نويسنده , , Alexander and Liao، نويسنده , , Xiaodong and Iglehart، نويسنده , , J. Dirk and Livingston، نويسنده , , David M. and Ganesan، نويسنده , , Shridar، نويسنده ,
Abstract :
Summary
ic basal-like cancers (BLC) are a distinct class of human breast cancers that are phenotypically similar to BRCA1-associated cancers. Like BRCA1-deficient tumors, most BLC lack markers of a normal inactive X chromosome (Xi). Duplication of the active X chromosome and loss of Xi characterized almost half of BLC cases tested. Others contained biparental but nonheterochromatinized X chromosomes or gains of X chromosomal DNA. These abnormalities did not lead to a global increase in X chromosome transcription but were associated with overexpression of a small subset of X chromosomal genes. Other, equally aneuploid, but non-BLC rarely displayed these X chromosome abnormalities. These results suggest that X chromosome abnormalities contribute to the pathogenesis of BLC, both inherited and sporadic.
