Author/Authors :
Takumi Yanaihara، نويسنده , , Nozomu and Caplen، نويسنده , , Natasha and Bowman، نويسنده , , Elise and Seike، نويسنده , , Masahiro and Kumamoto، نويسنده , , Kensuke and Yi، نويسنده , , Ming and Stephens، نويسنده , , Robert M. and Okamoto، نويسنده , , Aikou and Yokota، نويسنده , , Jun and Tanaka، نويسنده , , Tadao and Calin، نويسنده , , George Adrian and Liu، نويسنده , , Chang-Gong and Croce، نويسنده , , Carlo M. and Harris، نويسنده , , Curtis C.، نويسنده ,
Abstract :
Summary
NA (miRNA) expression profiles for lung cancers were examined to investigate miRNAʹs involvement in lung carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate lung cancers from noncancerous lung tissues as well as molecular signatures that differ in tumor histology. miRNA expression profiles correlated with survival of lung adenocarcinomas, including those classified as disease stage I. High hsa-mir-155 and low hsa-let-7a-2 expression correlated with poor survival by univariate analysis as well as multivariate analysis for hsa-mir-155. The miRNA expression signature on outcome was confirmed by real-time RT-PCR analysis of precursor miRNAs and crossvalidated with an independent set of adenocarcinomas. These results indicate that miRNA expression profiles are diagnostic and prognostic markers of lung cancer.
