Title of article
Targeted Expression of BikDD Eradicates Pancreatic Tumors in Noninvasive Imaging Models
Author/Authors
Xie، نويسنده , , Xiaoming and Xia، نويسنده , , Weiya and Li، نويسنده , , Zhongkui and Kuo، نويسنده , , Hsu-Ping and Liu، نويسنده , , Yuanfang and Li، نويسنده , , Zheng-Rong Ding، نويسنده , , Qingqing and Zhang، نويسنده , , Su and Spohn، نويسنده , , Bill Z. Yang، نويسنده , , Yan and Wei، نويسنده , , Yongkun and Lang، نويسنده , , Jing-Yu and Evans، نويسنده , , Douglas B. and Chiao، نويسنده , , Paul J. and Abbruzzese، نويسنده , , James L. and Hung، نويسنده , , Mien-Chie، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
14
From page
52
To page
65
Abstract
Summary
atic cancer is an aggressive malignancy with morbidity rates almost equal to mortality rates because of the current lack of effective treatment options. Here, we describe a targeted approach to treating pancreatic cancer with effective therapeutic efficacy and safety in noninvasive imaging models. We developed a versatile expression vector “VISA” (VP16-GAL4-WPRE integrated systemic amplifier) and a CCKAR (cholecystokinin type A receptor) gene-based, pancreatic-cancer-specific promoter VISA (CCKAR-VISA) composite to target transgene expression in pancreatic tumors in vivo. Targeted expression of BikDD, a potent proapoptotic gene driven by CCKAR-VISA, exhibited significant antitumor effects on pancreatic cancer and prolonged survival in multiple xenograft and syngeneic orthotopic mouse models of pancreatic tumors with virtually no toxicity.
Keywords
CELLCYCLE
Journal title
Cancer Cell
Serial Year
2007
Journal title
Cancer Cell
Record number
1336466
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