Title of article
The Extracellular Matrix Protein TGFBI Induces Microtubule Stabilization and Sensitizes Ovarian Cancers to Paclitaxel
Author/Authors
Ahmed، نويسنده , , Ahmed Ashour and Mills، نويسنده , , Anthony D. and Ibrahim، نويسنده , , Ashraf E.K. and Temple، نويسنده , , Jillian and Blenkiron، نويسنده , , Cherie and Vias، نويسنده , , Maria and Massie، نويسنده , , Charlie E. and Iyer، نويسنده , , N. Gopalakrishna and McGeoch، نويسنده , , Adam and Crawford، نويسنده , , Robin and Nicke، نويسنده , , Barbara and Downward، نويسنده , , Julian and Swanton، نويسنده , , Charles E. Bell، نويسنده , , Stephen D. and Earl، نويسنده , , Helena M. and Laskey، نويسنده , , Ronald A. and Caldas، نويسنده , , Carlos and Brenton، نويسنده , , James D.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
14
From page
514
To page
527
Abstract
Summary
tracellular matrix (ECM) can induce chemotherapy resistance via AKT-mediated inhibition of apoptosis. Here, we show that loss of the ECM protein TGFBI (transforming growth factor beta induced) is sufficient to induce specific resistance to paclitaxel and mitotic spindle abnormalities in ovarian cancer cells. Paclitaxel-resistant cells treated with recombinant TGFBI protein show integrin-dependent restoration of paclitaxel sensitivity via FAK- and Rho-dependent stabilization of microtubules. Immunohistochemical staining for TGFBI in paclitaxel-treated ovarian cancers from a prospective clinical trial showed that morphological changes of paclitaxel-induced cytotoxicity were restricted to areas of strong expression of TGFBI. These data show that ECM can mediate taxane sensitivity by modulating microtubule stability.
Keywords
CHEMBIO , CELLBIO , CELLCYCLE
Journal title
Cancer Cell
Serial Year
2007
Journal title
Cancer Cell
Record number
1336518
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