Unholy Matrimony: Aurora A and N-Myc as Malignant Partners in Neuroblastoma

Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora Aʹs potential as a therapeutic target.