Title of article :
DUB-le Trouble for Cell Survival
Author/Authors :
Opferman، نويسنده , , Joseph T. and Green، نويسنده , , Douglas R.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
Expression of MCL-1 is frequently elevated in cancer and is implicated in the resistance to chemotherapy by the BCL-2 small molecule inhibitor ABT-737. A recent paper in Nature identified USP9X as an antagonist of MCL-1 ubiquitinylation and degradation. Often upregulated in tumor cells, USP9X activity influences the response to ABT-737.
Journal title :
Cancer Cell
Journal title :
Cancer Cell
