Author/Authors :
Chen، نويسنده , , Ruihuan and Nishimura، نويسنده , , Merry C. and Bumbaca، نويسنده , , Stephanie M. and Kharbanda، نويسنده , , Samir and Forrest، نويسنده , , William F. and Kasman، نويسنده , , Ian M. and Greve، نويسنده , , Joan M. and Soriano، نويسنده , , Robert H. and Gilmour، نويسنده , , Laurie L. and Rivers، نويسنده , , Celina Sanchez and Modrusan، نويسنده , , Zora and Nacu، نويسنده , , Serban and Guerrero، نويسنده , , Steve and Edgar، نويسنده , , Kyle A. and Wallin، نويسنده , , Jeffrey J. and Lamszus، نويسنده , , Katrin and Westphal، نويسنده , , Manfred and Heim، نويسنده , , Susanne and James، نويسنده , , C. David and VandenBerg، نويسنده , , Scott R. and Costello، نويسنده , , Joseph F. and Moorefield، نويسنده , , Scott and Cowdrey، نويسنده , , Cynthia J. and Prados، نويسنده , , Michael and Phillips، نويسنده , , Heidi S.، نويسنده ,
Abstract :
Summary
ural stem cell marker CD133 is reported to identify cells within glioblastoma (GBM) that can initiate neurosphere growth and tumor formation; however, instances of CD133− cells exhibiting similar properties have also been reported. Here, we show that some PTEN-deficient GBM tumors produce a series of CD133+ and CD133− self-renewing tumor-initiating cell types and provide evidence that these cell types constitute a lineage hierarchy. Our results show that the capacities for self-renewal and tumor initiation in GBM need not be restricted to a uniform population of stemlike cells, but can be shared by a lineage of self-renewing cell types expressing a range of markers of forebrain lineage.
