Author/Authors :
Bruno، نويسنده , , Tiziana and Desantis، نويسنده , , Agata and Bossi، نويسنده , , Gianluca and Di Agostino، نويسنده , , Silvia and Sorino، نويسنده , , Cristina and De Nicola، نويسنده , , Francesca and Iezzi، نويسنده , , Simona and Franchitto، نويسنده , , Annapaola and Benassi، نويسنده , , Barbara and Galanti، نويسنده , , Sergio and La Rosa، نويسنده , , Francesca and Floridi، نويسنده , , Aristide and Bellacosa، نويسنده , , Alfonso and Passananti، نويسنده , , Claudio and Blandino، نويسنده , , Giovanni and Fanciulli، نويسنده , , Maurizio، نويسنده ,
Abstract :
Summary
is a RNA polymerase II binding protein involved in the regulation of gene transcription and, in response to DNA damage, promotes p53 transcription. In this study, we investigated whether Che-1 regulates mutant p53 expression. We found that Che-1 is required for sustaining mutant p53 expression in several cancer cell lines, and that Che-1 depletion by siRNA induces apoptosis both in vitro and in vivo. Notably, loss of Che-1 activates DNA damage checkpoint response and induces transactivation of p73. Therefore, these findings underline the important role that Che-1 has in survival of cells expressing mutant p53.
