Author/Authors :
Hou، نويسنده , , Jin and Lin، نويسنده , , Li and Zhou، نويسنده , , Weiping and Wang، نويسنده , , Zhengxin and Ding، نويسنده , , Guoshan and Dong، نويسنده , , Qiongzhu and Qin، نويسنده , , Lunxiu and Wu، نويسنده , , Xiaobing and Zheng، نويسنده , , Yuanyuan and Yang، نويسنده , , Yun-Qi Tian، نويسنده , , Wei and Zhang، نويسنده , , Qian and Wang، نويسنده , , Chunmei and Zhang، نويسنده , , Qinghua and Zhuang، نويسنده , , Shi-Mei and Zheng، نويسنده , , Limin and Liang، نويسنده , , Anmin and Tao، نويسنده , , Wenzhao and Cao، نويسنده , , Xuetao، نويسنده ,
Abstract :
Summary
ll scale of human miRNome in specific cell or tissue, especially in cancers, remains to be determined. An in-depth analysis of miRNomes in human normal liver, hepatitis liver, and hepatocellular carcinoma (HCC) was carried out in this study. We found nine miRNAs accounted for ∼88.2% of the miRNome in human liver. The third most highly expressed miR-199a/b-3p is consistently decreased in HCC, and its decrement significantly correlates with poor survival of HCC patients. Moreover, miR-199a/b-3p can target tumor-promoting PAK4 to suppress HCC growth through inhibiting PAK4/Raf/MEK/ERK pathway both in vitro and in vivo. Our study provides miRNomes of human liver and HCC and contributes to better understanding of the important deregulated miRNAs in HCC and liver diseases.
