Author/Authors :
Blobel، نويسنده , , Gerd A. and Kalota، نويسنده , , Anna and Sanchez، نويسنده , , Patricia V. and Carroll، نويسنده , , Martin، نويسنده ,
Abstract :
Targeting chromatin regulators for the treatment of malignancies has shown great promise, but also revealed significant challenges. By employing an elegant shRNA screen and a selective pharmacological inhibitor, a recent study published in Nature establishes the bromodomain protein Brd4 as novel target in acute myeloid leukemia (AML).
