Author/Authors :
Kawauchi، نويسنده , , Daisuke and Robinson، نويسنده , , Giles and Uziel، نويسنده , , Tamar and Gibson، نويسنده , , Paul and Rehg، نويسنده , , Jerold and Gao، نويسنده , , Cuilan and Finkelstein، نويسنده , , David and Qu، نويسنده , , Chunxu and Pounds، نويسنده , , Stanley and Ellison، نويسنده , , David W. and Gilbertson، نويسنده , , Richard J. and Roussel، نويسنده , , Martine F.، نويسنده ,
Abstract :
Summary
oblastomas that display a large cell/anaplastic morphology and overexpress the cellular c-MYC gene are highly aggressive and carry a very poor prognosis. This so-called MYC-subgroup differs in its histopathology, gene expression profile, and clinical behavior from other forms of medulloblastoma. We generated a mouse model of MYC-subgroup medulloblastoma by transducing Trp53-null cerebellar progenitor cells with Myc. The cardinal features of these mouse medulloblastomas closely mimic those of human MYC-subgroup tumors and significantly differ from mouse models of the Sonic-Hedgehog- and WNT-disease subgroups. This mouse model should significantly accelerate understanding and treatment of the most aggressive form of medulloblastoma and infers distinct roles for MYC and MYCN in tumorigenesis.
