Title of article
Opening a New GATAway for Treating KRAS-Driven Lung Tumors
Author/Authors
Barbacid، نويسنده , , Mariano، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
3
From page
598
To page
600
Abstract
In a recent issue of Cell, Kumar and colleagues uncovered a synthetic lethal interaction between oncogenic KRAS and the transcription factor GATA2 in non-small cell lung carcinoma. Pharmacological inhibition of GATA2-mediated pathways with bortezomib and fasudil results in dramatic tumor inhibition. These observations unveil new armamentaria to fight this deadly disease.
Journal title
Cancer Cell
Serial Year
2012
Journal title
Cancer Cell
Record number
1337884
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