Title of article
Phosphoglycerate Mutase 1 Coordinates Glycolysis and Biosynthesis to Promote Tumor Growth
Author/Authors
Hitosugi، نويسنده , , Taro and Zhou، نويسنده , , Lu and Elf، نويسنده , , Shannon and Fan، نويسنده , , Jun and Kang، نويسنده , , Hee-Bum and Seo، نويسنده , , Jae Ho and Shan، نويسنده , , Changliang and Dai، نويسنده , , Qing and Zhang، نويسنده , , Liang-Liang Xie، نويسنده , , Jianxin and Gu، نويسنده , , Ting-Lei and Jin، نويسنده , , Peng and Ale?kovi?، نويسنده , , Masa and LeRoy، نويسنده , , Gary Chih-Kang Liu، نويسنده , , Yibin and Sudderth، نويسنده , , Jessica A. and DeBerardinis، نويسنده , , Ralph J. and Luan، نويسنده , , Chi-Hao and Chen، نويسنده , , Georgia Z. and Muller، نويسنده , , Susan and Shin، نويسنده , , Dong M. and Owonikoko، نويسنده , , Taofeek K. and Lonial، نويسنده , , Sagar and Arellano، نويسنده , , Martha L. and Khoury، نويسنده , , Hanna J. and Khuri، نويسنده , , Fadlo R. and Lee، نويسنده , , Benjamin H. and Ye، نويسنده , , Keqiang and Boggon، نويسنده , , Titus J. and Kang، نويسنده , , Sumin and He، نويسنده , , Chuan and Chen، نويسنده , , Jing، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2012
Pages
16
From page
585
To page
600
Abstract
Summary
unclear how cancer cells coordinate glycolysis and biosynthesis to support rapidly growing tumors. We found that the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1), commonly upregulated in human cancers due to loss of TP53, contributes to biosynthesis regulation in part by controlling intracellular levels of its substrate, 3-phosphoglycerate (3-PG), and product, 2-phosphoglycerate (2-PG). 3-PG binds to and inhibits 6-phosphogluconate dehydrogenase in the oxidative pentose phosphate pathway (PPP), while 2-PG activates 3-phosphoglycerate dehydrogenase to provide feedback control of 3-PG levels. Inhibition of PGAM1 by shRNA or a small molecule inhibitor PGMI-004A results in increased 3-PG and decreased 2-PG levels in cancer cells, leading to significantly decreased glycolysis, PPP flux and biosynthesis, as well as attenuated cell proliferation and tumor growth.
Journal title
Cancer Cell
Serial Year
2012
Journal title
Cancer Cell
Record number
1338083
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