Title of article
Pharmacological Evaluation of Sedative activity of methanolic extract of Thuja occidentalis in mice.
Author/Authors
Aziz، H. Abdul نويسنده , , Ahmad Khan، Imran نويسنده Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan , , Hussain ، Musaddique نويسنده School of Pharmacy, The University of Faisalabad, Faisalabad, Pakistan , , Asif Raza، Muhammad نويسنده 3University Of Agriculture, Faisalabad (Sub campus Dera Ghazi Khan), Pakistan ,
Issue Information
روزنامه با شماره پیاپی سال 2014
Pages
9
From page
202
To page
210
Abstract
The methanolic leaf extract of Thuja occidentalis was evaluated for possible sedative activities in mice. Sedative activity was evaluated by using hole cross, open field, thiopental sodium-induced sleeping time and elevated-plus maze (EPM) tests at 200mg/kg and 400 mg/kg. The extract decreased the locomotor activity of mice in hole cross, open field and EPM test and showed the remarkable results as compared to the standard at both mentioned doses. Moreover, the extractsignificantly minimized onset of sleep and maximized the duration of sleeping time when administered with thiopental sodium and statistically it was significant (p < 0.05).
Journal title
International Journal of Advanced Biological and Biomedical Research (IJABBR)
Serial Year
2014
Journal title
International Journal of Advanced Biological and Biomedical Research (IJABBR)
Record number
1348750
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