Author/Authors :
Johari، Habiballah نويسنده Department of Physiology, Darab Branch, Islamic Azad University, Darab, Iran Johari, Habiballah , Nozari، Mohsen نويسنده Department of Physiology, Kazeron Branch, Islamic Azad University, Kazeron, Iran Nozari, Mohsen , Moghtari، Moghtar نويسنده Department of Physiology, Kazeron Branch, Islamic Azad University, Kazeron, Iran Moghtari, Moghtar , Zamani، Zahra نويسنده Department of Medicinal Chemistry, Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran , , Yazdani، Mohammad نويسنده Department of Agriculture, Firouz Abad Branch, Islamic Azad University, Firouz Abad, Iran Yazdani, Mohammad
Abstract :
Background: The aim of this study was the effect of Myrtus communis extract on liver enzymes and blood biochemical factors in diabetic adult male rats.
Materials and Methods: This study has been carried out experimentally and completely random. Seventy adult male Wistar rats were divided in 7 groups including: control which received no treatment, sham who received 2 mL of distilled water, the 1st, 2nd and 3rd experimental groups which received 0.75, 1.5 and 3 mg/kg Myrtus communis leaf extract respectively, the 4th experimental group as the diabetic control group who received streptozotocin (60 mg/kg) and the 5th experimental group as the diabetic treatment group who received 3 mg/kg of extract. This experiment lasted 14 days with prescript orally. After this period, all the rats, were weighted, anesthetized and blood samples were taken from the heart centrifuged and sera were evaluated for the concentration of various factors. In addition liver were removed and sliced.
Results: According to the obtained results, the plasma concentration of liver enzyme (alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase), cholesterol and glucose presented a significant decrease at (p?0.05). Whereas no significant change were seen in body weight, triglyceride, urea, albumin and total protein. Histological studies of the liver tissue showed no significant difference among various groups.
Conclusion: Myrtus communis is comprise of collections of flavonoids and other various components with antioxidant and anti inflammatory properties. Thence it can effective in treatment of liver diseases and decrease of blood sugar and cholesterol in diabetes mellitus patients.
