Preparation of pyrimidin-2-one derivatives via base-mediated decomposition of uracil-analogues Fischer carbene complex

A practical and efficient synthesis of pyrimidin-2-one derivatives from Fischer carbene complex uracil-analogues through base-mediated elimination reactions is described. The scope of the protocol has been explored with the preparation of a variety of pyrimidin-2-one derivatives by base mediated demetallation of N-1 and N-3 substituted uracil Fischer carbenes.